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Person with firm and toned skin representing Ultherapy PRIME® personalized ultrasound skin lifting treatment


Actual patient - posterior arms not treated. Individual results may vary.

­ULTHERAPY PRIME®
DISCOVER YOUR SIGNATURE LIFT

Meet Ultherapy PRIME® —an advanced, vivid ultrasound technology that tailors treatment to your skin’s unique needs for a truly personal lift. It’s a non-invasive way to lift and sculpt the upper face, lower face, neck and décolleté1-3 and give you firmer, more toned skin on your arms and abdomen.*,1,4,5 Real-time visualization allows your practitioner to see exactly where you need to be treated—creating a personalized‡ lift that truly lasts.†, 1-3,6,7 And what’s more? This treatment can have you looking and feeling your best with just one visit and no downtime required.

SEE WHY SALMA LOVES ULTHERAPY PRIME®

I’m so happy with my results, ULTHERAPY PRIME® really is the Lift You Can SEE!

Salma Hayek testimonial and signature highlighting Ultherapy PRIME® lifting results

HOW ULTHERAPY PRIME® WORKS

THE TREATMENT AREAS OF
ULTHERAPY PRIME®

Illustration of Ultherapy PRIME® treatment areas including face, neck, décolleté, arms, and abdomen.

PERSONALIZED TREATMENT,
VISIBLE RESULTS

Before-and-after side view showing facial lifting and jawline definition with Ultherapy® non-invasive ultrasound treatment
Before
Before-and-after side view showing facial lifting and jawline definition with Ultherapy® non-invasive ultrasound treatment
After

ULTHERAPY® patient and model. Individual results may vary; please consult your doctor. The “after” photo was taken 6 months after treatment. None of the photos have been retouched.

Before-and-after front view demonstrating facial skin tightening and lifting with Ultherapy® ultrasound technology
Before
Before-and-after front view demonstrating facial skin tightening and lifting with Ultherapy® ultrasound technology
After

ULTHERAPY® patient and model. Individual results may vary; please consult your doctor. The “after” photo was taken 6 months after treatment. None of the photos have been retouched.

Before-and-after skin lift of the face after Ultherapy® treatment
Before
Before-and-after skin lift of the face after Ultherapy® treatment
After

ULTHERAPY® patient and model. Individual results may vary; please consult your doctor. The “after” photo was taken 6 months after treatment. None of the photos have been retouched.

Before-and-after abdomen skin firming with Ultherapy PRIME® non-invasive ultrasound treatment
Before
Before-and-after abdomen skin firming with Ultherapy PRIME® non-invasive ultrasound treatment
After

ULTHERAPY® patient and model. Individual results may vary; please consult your doctor. The “after” photo was taken 6 months after treatment. None of the photos have been retouched.

TRUST WHAT YOU SEE.

A LEADER IN NONINVASIVE SKIN LIFTING.

Gold Standard recognition highlighting Ultherapy PRIME® as a leading non-invasive lifting treatment

Ultherapy PRIME® is the evolution of Ultherapy® Legacy that has been recognized by a body of expert physicians as the Gold Standard for nonsurgical skin lifting because it has2:

  • The strongest* body of clinical evidence backed by more than 120 publications
  • Unique technology
  • High patient satisfaction, 95% at year one7

*Strongest among non-invasive aesthetic ultrasound devices.

Award recognizing Ultherapy PRIME® as a leading choice for non-invasive skin lifting

A Leading Choice for Noninvasive Skin Lifting Treatments1,22‡

Ultherapy PRIME® is a leading choice for nonsurgical lift without downtime. Backed by years of clinical research and trusted in over 4 million treatments worldwide, Ultherapy® sets the benchmark for proven, long-lasting results§ in just 1 session.2,7,22

‡ Based on total revenue from noninvasive aesthetic energy-based devices.

§ Ultherapy PRIME® results can last up to 6 months for the abdomen and arms and a year or more in the face.

Cosmopolitan Holy Grail Beauty Award 2025 recognition for Ultherapy PRIME®

Ultherapy PRIME® has been recognized by Cosmopolitan with the Cosmopolitan Holy Grail Beauty Award 2025.

FREQUENTLY ASKED QUESTIONS ABOUT ULTHERAPY PRIME®

Ultherapy PRIME® builds on the established safety profile of Ultherapy® with over 50 clinical studies, and over 3.5 million treatments* in more than 80 countries worldwide.2,6,7,8,16 In addition, ultrasound energy has a proven track record, with use in the field of medicine for more than 50 years.

Ultherapy PRIME® is a non-surgical technology that uses microfocused ultrasound technology with real-time visualization, designed to activate your collagen and elastin production, to lift and sculpt the upper face, lower face, neck and décolleté and for improved skin laxity on your arms and abdomen.1,5 It is the ONLY non-invasive treatment to use vivid integrated real-time ultrasound imaging to actually SEE where the treatment will be most beneficial for you, giving you truly personalized long-lasting** results along with younger looking skin.2,5,6,14,15

No. With Ultherapy PRIME®, there is no downtime.1 After your treatment, you can resume your normal activities immediately following the instructions  of your practitioner. Treatment sessions with Ultherapy PRIME® are now 20% faster†, so you can get back to your day even sooner.17 

Since your treatment stimulates your body’s own collagen and elastin production the results may vary on each individual person. You may see some initial lifting and firming, but the ultimate results will take place over two to three months, as the production of new collagen and elastin replaces old tissue targeted by the treatment. A single Ultherapy PRIME® treatment can give a lasting effect for up to a year or more on the face and 6 months or more on the body.**
The results may vary from person to person. Your practitioner will advise on the likely outcome for you.1,2,5-7,12-15 

As the microfocused ultrasound energy is delivered, you may feel discomfort as tiny amounts of energy are being deposited to precise depths, stimulating the collagen- and elastin-building process. Treatment comfort levels vary from person to person and your practitioner will discuss your personalized comfort management plan with you.

Ultherapy PRIME® is suited for those with mild to moderate skin laxity in the face and the body‡ who prefer a non-invasive approach with no downtime and natural-looking results that gradually improve  over time.2,9,12,13,14,20

You may be a suitable candidate for this treatment if you’re experiencing changes in your appearance of your arms and abdomen due to factors such as age, weight fluctuations, postpartum, or menopause.18,19

Ultherapy PRIME® is suitable for all skin tones.1,16 It is not recommended for those with significant weight loss resulting in pronounced skin laxity.1,3,12,21

Ultherapy PRIME® uses a unique integrated real-time imaging technology. This allows your practitioner to assess below your skin before and during the treatment to see and precisely target your collagen and elastin-rich skin layers.1,2,9 

By personalizing the treatment to your unique skin anatomy, Ultherapy PRIME® promotes long-lasting**, natural-looking results.2,7,8,14,15 

Results can be visible after only one session that takes between 30-90 minutes depending on the areas to be treated. Your practitioner will define the right treatment protocol for you.

†Average reported increase in system speed over legacy Ultherapy® device based on a survey of providers.

*Performed with legacy Ultherapy® and Ultherapy PRIME®

**Ultherapy PRIME® results can last up to 6 months for the arms and abdomen and a year or more in the face. Face refers to cleared indications for Ultherapy PRIME®.

‡Ultherapy PRIME® System is intended for non-invasive dermatological sculpting and lifting of the skin of the upper face, lower face, neck and décolleté, and to improve the appearance of skin laxity on the abdomen, anterior arms, and posterior arms

  1. Ulthera® Instructions for Use.
  2. Fabi SG, Joseph J, Sevi J, Green JB, Peterson JD. Optimizing patient outcomes by customizing treatment with microfocused ultrasound with visualization: gold standard consensus guidelines from an expert panel. J Drugs Dermatol. 2019;18(5):426-432.
  3. Park JY, et al. Customized Treatment Using Microfocused Ultrasound with Visualization for Optimized Patient Outcomes: A Review of Skintightening Energy Technologies and a Pan-Asian Adaptation of the Expert Panel’s Gold Standard Consensus. J Clin Aesthet Dermatol. 2021;14(5):E70-E79.
  4. Whitney ZB, Zito PM. Anatomy, skin, superficial musculoaponeurotic system (SMAS) fascia. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2019. https://www.ncbi.nlm.nih.gov/books/NBK519014/. Updated October 27, 2018. Accessed December 9, 2019.
  5. Suh DH, Choi JH, Lee SJ, Jeong KH, Song KY, Shin MK. Comparative histometric analysis of the effects of high-intensity focused ultrasound and radiofrequency on skin. J Cosmet Laser Ther. 2015;17(5):230-236.
  6. Fabi SG, Massaki A, Eimpunth S, Pogoda J, Goldman MP. Evaluation of microfocused ultrasound with visualization for lifting, tightening, and wrinkle reduction of the décolletage. J Am Acad Dermatol. 2013;69(6):965-971.
  7. Werschler WP, Werschler PS. Longterm efficacy of micro-focused ultrasound with visualization for lifting and tightening lax facial and neck skin using a customized vectoring treatment method. J Clin Aesthet Dermatol. 2016;9(2):27-33.
  8. Pavicic T, Ballard JR, Bykovskaya T, et al. Microfocused ultrasound with visualization: Consensus on safety and review of energy-based devices. J Cosmet Dermatol. 2021.
  9. Sasaki G, Grossman J, Fabi SG, et al. Stimulation of Collagen Synthesis in Human Skin Following Microfocused Ultrasound Therapy. Presented at the ASDS 2018 Annual Meeting.
  10. White WM, Makin IR, Barthe PG, Slayton MN, Gliklich RE. Selective creation of thermal injury zones in the superficial musculoaponeurotic system using intense ultrasound therapy: a new target for noninvasive facial rejuvenation. Arch Facial Plast Surg. 2007;9(1):22-29.
  11. Data on file. Number of Ultherapy Treatments. Merz Aesthetics 2024.
  12. Sasaki GH, Tevez A. Microfocused ultrasound for nonablative skin and subdermal tightening to the periorbitum and body sites: Preliminary report on eighty-two patients. J Cosmet Dermatol Sci Appl. 2012;02(02):108-116.
  13. Vachiramon V, Triyangkulsri K, Iamsumang W, Chayavichitsilp P. Efficacy and safety of microfocused ultrasound with visualization in abdominal skin laxity: A randomized, comparative study. Lasers Surg Med. 2020;52(10):825-832. doi:10.1002/lsm.23234.
  14. Lin F. Nonsurgical Treatment of Postpartum Lower Abdominal Skin and Soft-Tissue Laxity Using Microfocused Ultrasound With Visualization. Amer Soc for Derm Surg., Published by Wolters Kluwer Health, Inc. ISSN: 1076-0512. 2020.
  15. Alster TS, Tanzi EL. Noninvasive lifting of arm, thigh, and knee skin with transcutaneous intense focused ultrasound. Dermatol Surg. 2012 May;38(5):754-9. doi:10.1111/j.1524-4725.2012.02338.x. Epub 2012 Jan 23. PMID: 22268509.
  16. Merz Aesthetics Data on file 2025.
  17. Levine J, McCarthy AD, Pavicic T, et al. Comparative Ultrasound Visualization Analysis Between Ultherapy® and Ultherapy PRIME® and Survey and Clinical Case Results from the Ultherapy PRIME® Early Experience Program. 2024. Data on File.
  18. Wines N, Willsteed E. Menopause and the skin. Australasian Journal of Dermatology. 2001;42:149-160. https://doi.org/10.1046/j.1440-0960.2001.00524.x
  19. Hall G, Phillips TJ. Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol. 2005 Oct;53(4):555-568; quiz 569-572. doi:10.1016/j.jaad.2004.08.039. PMID: 16198774.
  20. Wollina U, Goldman A. Upper arm contouring – a narrative review. Georgian Med News. 2022;11(332).
  21. Marquardt K, Hartmann C, Wegener F, et al. Microfocused ultrasound with visualization induces remodeling of collagen and elastin within the skin. J Cosmet Dermatol. 2025;24(1):e16638. doi:10.1111/jocd.16638
  22. Based on total revenue from non-invasive aesthetic energy-based devices, derived from earnings reports (Bausch Health, InMode, Classys, Sofwave, Wontech and Beauty Health), independent market data, and internal data on file, September 2025.